Drug Discovery Research Screening Libraries
Enzo Life Sciences SCREEN-WELL Cardiotoxicity library (500 µl/well)
The SCREEN-WELL Cardiotoxicity Library is a focused collection of 130 compounds with defined and diverse cardiotoxicity, including ion channel blockage, mitochondrial toxicity, arrhythmia, fibrosis, and many more. A variety of structurally and mechanistically different compound classes are included, as well as nontoxic controls. The compounds are dissolved in DMSO at 10mM and aliquoted into deep-well plates. The library is an essential tool for predictive toxicology screening and assay development. Long Term Storage: -80°C. Applications: HTS .
Abcam PP3, Negative control for PP2, 100MG
MW 211.22 Da, Purity >97%. Negative control for the Src kinase inhibitor PP2 (ab120308). Inhibits EGFR kinase (IC₅₀ = 2.7 μM).
The product is subject to the following: Abcam Restricted Use Statement
Cayman Chemical Terpen Screeng LIbrary 50uL
An inhibitor of the menin-MLL1 fusion protein interaction (Ki 0.104 nM) selectively inhibits the growth of ten leukemia cell lines expressing MLL1 fusion proteins (IC50s 13-37 nM) over HL-60 K562 and Reh leukemia cells expressing wild-type MLL1 (IC50s >1000 nM) reduces MLL-AF9-induced increases in the expression of MLL fusion protein target genes in MOLM-13 leukemia cells dramatically increases the survival of mice in a PDX mouse model of B-ALL at 120 mg/kg twice per day
Abcam GANT58, Hh signaling inhibitor, 50MG
MW 392.48 g/mol, Purity >99%. Inhibits Hh signaling downstream of smo and sufu. IC₅₀ = 5 μM for glioma associated oncogene expression in MEFs.
The product is subject to the following: Abcam Restricted Use Statement
Selleck Chemical LLC Cambridge Cancer Compound Library 100uL/well
A unique collection of 247 anti-cancer compounds for high throughput screening (HTS) and high content screening (HCS). *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Anti-infection Compound Library 100uL/well
A unique collection of 1415 anti-infection compounds with biological activity of antibacterial,antifungal,antiviral,etc. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Tyrosine Kinase Inhibitor Library 100uL/well
A unique collection of 513 tyrosine kinase inhibitors for high throughput screening (HTS) and high content screening (HCS). *For Research & Development use only. Product is not intended for drug, household, or human consumption.
AdipoGen S-Benzoylthiamine O-PO4
Chemical. CAS 22457-89-2. Formula C19H23N4O6PS. MW 466.45. S-Benzoylthiamine O-monophosphate is a lipid-soluble form of vitamin B1 thiamine. S-Benzoylthiamine O-monophosphate facilitates the action of thiamine diphosphate, a cofactor for the enzyme transketolase. The activation of transketolase enzyme accelerates the precursors of advanced glycation end products AGEs towards the pentose phosphate pathway thereby reducing the production of AGEs. The reduction in AGEs subsequently decreases metabolic stress which benefits vascular complications seen in diabetes. The anti-AGE property of S-Benzoylthiamine O-monophosphate certainly makes it effective for the treatment of diabetic neuropathy, nephropathy and retinopathy. S-Benzoylthiamine O-monophosphate appears to have a also cardioprotective role in potentiating angiogenesis and inhibiting apoptosis in diabetic complications.
AdipoGen C12-L-HSL
Chemical. CAS 137173-46-7. Formula C16H29NO3. MW 283.4. Synthetic. N-Dodecanoyl-L-homoserine lactone C12-HSL is a small diffusible signalling molecule involved in quorum sensing, thereby controlling gene expression and affecting cellular metabolism in bacteria. In addition to regulating bacterial functions, C12-HSL activates NF-kappaB in RAW 264.7 macrophages, increasing the expression of TNF-alpha, interleukin-1beta IL-1beta and IL-8, while other lactones do not. In addition, C12-HSL alters cell cycling and metabolism of human keratinocyte HaCaT cells. It is important to note that C12-HSL is distinct from N-3-oxo-dodecanoyl-L-homoserine lactone, which is produced at different times in biofilm development and has different cellular effects.
AdipoGen Acetamidofluorescein
Chemical. CAS 82779-14-4. Formula C22H15NO6. MW 389.36. Acetamidofluorescein is a N-acetyl derivative of fluorescein that is strongly fluorescent und used as a fluorescent label. Spectral data lambdaex = 491nm, lambdaem 515nm.
AdipoGen 3-4-Aminophenyl-7-diethylam
Chemical. CAS 36840-64-9. Formula C20H22N2O2. MW 322.4. Fluorogenic amine label used for the synthesis of fluorescent reagents. Spectral Data lambdaex = 396nm lambdaem = 480nm in DMF, Lit.
AdipoGen D-Aspartic acid
Chemical. CAS 1783-96-6. Formula C4H7NO4. MW 133.1. Synthetic. Endogenous NMDA receptor agonist with similar activity to the L-isomer. Endogenous amino acid present in vertebrates and invertebrates, plays an important role in the neuroendocrine system, as well as in the development of the nervous system. Acts as a neurotransmitter/neuromodulator. Increases cAMP in neuronal cells and is transported from the synaptic clefts to presynaptic nerve cells through a specific transporter. In the endocrine system, D-Asp is involved in the regulation of hormone synthesis and release. Enhances gonadotropin-releasing hormone GnRH release and induces oxytocin and vasopressin mRNA synthesis in rats. In the pituitary gland, it stimulates the secretion of the hormones prolactin PRL, luteinizing hormone LH and growth hormone GH. Also involved in testosterone and progesterone release.
Selleck Chemical LLC Inhibitor Library 100uL/well
A unique collection of 3455 inhibitors for high throughput screening (HTS) and high content screening (HCS). *For Research & Development use only. Product is not intended for drug, household, or human consumption.