Drug Discovery Research Screening Libraries
Apexbio Technology LLC DiscoveryProbe™ Metabolism-related Compound Library, 100uL/well(10 mM solution), 96 Well Racks With Screw Cap
A unique collection of 493 metabolism-related compounds for metabolism research. Other sizes are available. Please inqury us for quote.
Enzo Life Sciences SCREEN-WELL Natural Product library (500 µl/well)
Natural products are an unsurpassed source of chemical diversity and an ideal starting point for any screening program for pharmacologically active small molecules. Historically, natural products have been the most successful source of new drugs. The SCREEN-WELL Natural Product library offers over 500 isolated natural compounds of known structure and includes many compounds from ethnopharmacology. Compounds are provided in solution in DMSO. Individual compounds or subsets can be resupplied in gram quantities. Long Term Storage: -80°C. Applications: HTS .
Apexbio Technology LLC DiscoveryProbe™ Epigenetics Compound Library 100uL/well(10 mM solution),96 Well Deep Well Plate
DiscoveryProbe Epigenetics Compound Library comprises 328 small molecules specifically targeting known epigenetic regulators and is carefully curated for biomedical research The compounds in this collection modulate essential epigenetic targets including bromodomains histone deacetylases (HDACs) Janus kinases (JAKs) histone methyltransferases (HMTs) protein Ser/Thr phosphatases and histone acetyltransferases (HATs) Representative compounds include selective HDAC inhibitors bromodomain modulators and methyltransferase-targeting molecules Compounds are approved by recognized institutions or referenced extensively in scientific literature This library facilitates epigenetic mechanism studies target identification chemical biology research and pharmacogenomic exploration
Apexbio Technology LLC DiscoveryProbe™ FDA-approved Library, 250uL/well(10 mM solution),96 Well Racks With Screw Cap
DiscoveryProbe™ FDA-approved drug library includes 1971 FDA approved drugs for high throughput screening (HTS) and high content screening (HCS). It can be used to find new targets for old drugs. The bioactivity and safety of these drugs were confirmed by clinical trials. As they are all FDA-approved drugs, the drugs screened can be used for clinical testing directly. Other sizes are available, contact us for quote.
Apexbio Technology LLC DiscoveryProbe™ Immunology/Inflammation Compound Library, 250uL/well(10 mM solution), 96 Well Racks With Screw Cap
A unique collection of 295 small molecule compounds for immunology/inflammation research. Other sizes are available. Please inqury us for quote.
Enzo Life Sciences SCREEN-WELL Cancer Library (100µl/well)
The SCREEN-WELL Cancer Library is a collection of 275 compounds that can be used for cancer inhibitor screening and assay development. The library contains small molecules affecting mTOR, aurora kinases, tyrosine kinases, PI3K, and HDAC, as well as many structurally and mechanistically different compound classes. This library is an essential tool for cancer inhibitor screening and drug development. The compounds are dissolved in DMSO at 10 mM and aliquoted into 96-well deep-well plates at 100 µL per well. Long Term Storage: -80°C. Applications: HTS .
Apexbio Technology LLC DiscoveryProbe™ Metabolism-related Compound Library Plus, 100uL/well(10 mM solution), 96 Well Racks With Screw Cap
DiscoveryProbe™ Metabolism-related Compound Library Plus is a unique collection of 1205 metabolism-related compounds for metabolism research. Available in stock with overnight delivery and free shipping over $500 Cost-effective and competitive price to save your findings Potent, selective and cell-permeable in inhibiting or activating target molecules Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.) Detailed files describing potency, selectivity and applications etc. Supported by published data from top peer-reviewed journals Guaranteed high quality with NMR and HPLC validation. Other sizes are also available. Please inqury us for quote.
Apexbio Technology LLC DiscoveryProbe™ NF-B Signaling Compound Library Plus, 100uL/well(10 mM solution), 96 Well Racks With Screw Cap
DiscoveryProbe™ NF-B Signaling Compound Library Plus is a unique collection of 178 NF-B inhibitors for NF-B signaling pathway research. Available in stock with overnight delivery and free shipping over $500 Cost-effective and competitive price to save your findings Potent, selective and cell-permeable in inhibiting or activating target molecules Diverse in chemical structure and route of administration (oral/i.m/i.v injection etc.) Detailed files describing potency, selectivity and applications etc. Supported by published data from top peer-reviewed journals Guaranteed high quality with NMR and HPLC validation. Other sizes are also available. Please inqury us for quote.
Apexbio Technology LLC DiscoveryProbe™ Protease Inhibitor Library, 250uL/well(10 mM solution), 96 Well Racks With Screw Cap
A unique collection of 825 protease inhibitors for high throughput screening (HTS) and high content screening (HCS). Other sizes are available. Please inqury us for quote.
AdipoGen Anthralin
Chemical. CAS 1143-38-0. Formula C14H10O3. MW 226.2. Synthetic. Anthralin is a leukotriene biosynthesis inhibitor. It inhibits LTB4 omega-oxidation and disrupts mitochondria function. Anthralin is used in the treatment of psoriasis, as a fungicide, in the treatment of ringworm infections and in chronic dermatoses. It accumulates in mitochondria where it interferes with the supply of energy to the cell, probably by the oxidation of dithranol releasing free radicals. This impedes DNA replication and so slows the excessive cell division that occurs in psoriatic plaques. Numerous studies have demonstrated anti-proliferative and anti-inflammatory effects of anthralin on psoriatic and normal skin. It is also used as matrix substance for MALDI-MS matrix-assisted laser desorption ionization MS.
AdipoGen DNER ED hFc h rec
Protein. The extracellular domain of human DNER aa 29-637 is fused at the C-terminus to the Fc portion of human IgG1. Source HEK 293 cells. Endotoxin content <0.06EU/µg purified protein LAL test Lonza. Lyophilized from 0.2µm-filtered solution in PBS. Purity >90% SDS-PAGE. DNER is an activator of the Notch1 pathway. It mediates neuron-glia interaction during astrocytogenesis.
AdipoGen N-tert-Butyl-alpha-phenylnitro
Chemical. CAS 3376-24-7. Formula C11H15NO. MW 177.2. Synthetic. Cell permeable spin trap commonly used in free radical research for both in vivo and in vitro studies. It protects against oxidative damage caused by various inflammatory events, demonstrating neuroprotective, anti-anging, and antidiabetic effects. PBN has been shown to inhibit LPS-induced NF-kappaB DNA binding activity, inhibit COX-2 catalytic activity, inhibit lipid peroxidation in rat liver microsomes and prevent the induction of inducible nitric oxide synthase iNOS. Shows anti-cancer activity in several experimental cancer models.
AdipoGen Glyburide USP
Chemical. CAS 10238-21-8. Formula C23H28ClN3O5S. MW 494. Antidiabetic compound. Binds to and activates the ATP-sensitive potassium channels KATP inhibitory regulatory subunit sulfonylurea receptor 1 SUR1. Causes cell membrane depolarization and opening of voltage-dependent calcium channel. Increases intracellular calcium and stimulates insulin secretion in beta cells NLRP3 inflammasome inhibitor. Broad-spectrum ATP-binding cassette ABC transporter inhibitor. Shown to have anti-leishmanial activity. Potential inhibitor of collagenases.